NAD+

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell — central to energy metabolism, DNA repair, and sirtuin signaling, and a cornerstone molecule in longevity and metabolic research.

What it does in research models
As a redox coenzyme, NAD+ shuttles electrons through the reactions that generate cellular energy (ATP). It also serves as a required substrate for two enzyme families central to aging research: the sirtuins (SIRT1–7), which regulate gene expression, and the PARPs, which participate in DNA repair. Because both consume NAD+, its availability links a cell’s energy status to DNA maintenance — the mechanistic basis for much of the longevity interest.

Research context
NAD+ levels decline with age, which is why it is studied extensively in the context of mitochondrial function and cellular aging. It is the direct coenzyme form — distinct from precursors such as NMN and NR, which cells must convert into NAD+. This research-grade material is supplied for in-vitro and laboratory study only.

Often studied alongside other longevity and mitochondrial compounds — see SS-31 » (mitochondria-targeting peptide) and [Glutathione »] (master antioxidant tripeptide), or browse all Longevity Research » compounds.

Purity & testing
– ≥99% purity (this lot: 99.67% by HPLC)
– Lyophilized powder for laboratory reconstitution
– Batch-specific Certificate of Analysis — HPLC + mass spec, heavy metals, sterility, endotoxin
– ISO/IEC 17025-accredited third-party testing

Laboratory handling
NAD+ is hygroscopic and light-sensitive. Store lyophilized material cold, dry, and protected from light (long-term at −20 °C). After reconstitution, refrigerate at 2–8 °C and use within your protocol window. Confirm identity and purity against the batch COA before use.

Research FAQ
What is NAD+? A coenzyme (nicotinamide adenine dinucleotide) present in all living cells, essential to energy metabolism and used as a substrate by sirtuins and DNA-repair enzymes.
How is NAD+ different from NMN and NR? NMN and NR are precursors that cells convert into NAD+; this product is the NAD+ coenzyme itself.

For laboratory and research use only. Not for human or veterinary consumption, and not for diagnostic or therapeutic use. These statements have not been evaluated by the FDA.