MOTS-c is a mitochondrial-derived peptide (MDP) — a small peptide encoded within mitochondrial DNA — studied for its role in metabolic regulation, insulin sensitivity, and exercise capacity.
What makes it distinct
Unlike most peptides, MOTS-c originates from the mitochondrial genome rather than nuclear DNA. It is studied as a signaling molecule that links mitochondrial function to whole-body metabolism, with research focused on activation of the AMPK pathway — a central regulator of cellular energy — which is why it is sometimes described as an “exercise-mimetic” in the literature.
Research context
MOTS-c sits at the intersection of metabolic and longevity research: circulating levels are reported to decline with age, and it is studied in the context of metabolic flexibility, insulin sensitivity, and mitochondrial signaling. This research-grade material is supplied for in-vitro and laboratory study only.
Regulatory note (2026)
MOTS-c is among the peptides reviewed by the FDA’s Pharmacy Compounding Advisory Committee (July 23–24, 2026) for section 503A eligibility. That is a compounding-pharmacy question, distinct from FDA drug approval — MOTS-c is not FDA-approved, and VANTA’s material remains strictly research-use-only.
Related research compounds
Often studied alongside other mitochondrial and metabolic compounds — see [SS-31 »] (mitochondria-targeting peptide), [NAD+ »] (cellular-energy coenzyme), and [5-Amino-1MQ »] (NNMT-inhibiting metabolic compound), or browse all [Metabolic Research »] compounds.
Purity & testing
– ≥99% purity (this lot: 99.53% by HPLC)
– Lyophilized powder for laboratory reconstitution
– Batch-specific Certificate of Analysis — HPLC + mass spec, heavy metals, sterility, endotoxin
– ISO/IEC 17025-accredited third-party testing → [View the COA »]
Laboratory handling
Store lyophilized material cold and protected from light (long-term at −20 °C). After reconstitution, refrigerate at 2–8 °C and use within your protocol window. Confirm identity and purity against the batch COA before use.
Research FAQ
What is a mitochondrial-derived peptide? A peptide encoded by mitochondrial DNA rather than the cell’s nuclear genome; MOTS-c is one of the most-studied examples.
What is MOTS-c studied for? Metabolic regulation, insulin sensitivity, AMPK signaling, and exercise capacity, largely in metabolic and aging research models.
For laboratory and research use only. Not for human or veterinary consumption, and not for diagnostic or therapeutic use. These statements have not been evaluated by the FDA.
